Genetic deletion of phosphodiesterase 4D in the liver improves

pede4dPhosphodiesterase 4D (PDE4D) expression is upregulated in angiotensin (Ang) II-induced hypertensive mice. We first established a hypertensive model in wild-type (WT,Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory