Molecular mechanism of nur77 gene expression and downstream

nuri77The mechanism of Nur77 regulating cell survival and apoptosis in CNS. Nur77 mediates cell apoptosis through caspase, endoplasmic reticulum stress, and mitochondrial autophagy, whileFure 1 Loss of Nur77 in BMDMs leads to enhanced efferocytosis due to an increased integrin β3 and β5 snaling.(A) In vitro uptake of fluorescently-labeled apoptotic